TGF-BETA RECEPTOR TYPE II FUSION PROTEINS AND USES THEREOF
In certain aspects, the present disclosure relates to TβRII fusion polypeptides comprising a heterologous portion and a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and...
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| Main Authors | , |
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| Format | Patent |
| Language | English French German |
| Published |
01.11.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | In certain aspects, the present disclosure relates to TβRII fusion polypeptides comprising a heterologous portion and a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders. |
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| AbstractList | In certain aspects, the present disclosure relates to TβRII fusion polypeptides comprising a heterologous portion and a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders. |
| Author | SAKO, Dianne S KUMAR, Ravindra |
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| DocumentTitleAlternate | PROTÉINES DE FUSION DU RÉCEPTEUR TGF-BÊTA DE TYPE II ET UTILISATIONS ASSOCIÉES FUSIONSPROTEINE VOM TGF-BETA-REZEPTOR TYP II UND VERWENDUNGEN DAVON |
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| Notes | Application Number: EP20230171804 |
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| PublicationYear | 2023 |
| RelatedCompanies | Acceleron Pharma Inc |
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| Snippet | In certain aspects, the present disclosure relates to TβRII fusion polypeptides comprising a heterologous portion and a truncated, ligand-binding portion of... |
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| Title | TGF-BETA RECEPTOR TYPE II FUSION PROTEINS AND USES THEREOF |
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