MULTI-SPECIFIC ANTIGEN BINDING MOLECULES TARGETING HIV AND METHODS OF USE

• Main Authors: BACA, Manuel, GOLDSMITH, Joshua, BLAIR, Wade S, STEPHENSON, Heather T, PAN, YenRu, THOMSEN, Nathan D, HUNG, Magdeleine S, NAGEL, Mark, CLANCY, Sheila B, KANWAR, Manu, CARR, Brian A, MOLDT, Brian, PACE, Craig S
• Format: Patent
• Language: English; French; German
• Published: 05.07.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are multi-specific antigen binding molecules, including bispecific antibodies, that bind to CD3 and an HIV antigen, including HIV envelope protein gp120. Also provided are methods of using such antigen binding molecules to treat or prevent HIV infection.