INTERMEDIATES AND PROCESS FOR PREPARING L-DOPA DIPHOSPHATE

• Main Authors: MAYER, Peter T, ZHANG, Geoff G, DEMPAH, Kassibla E, KRABBE, Scott W, KYM, Philip R, HUTERS, Alexander D, MILLER, Christopher P, HENRY, Rodger F, HUANG, Ye, MACKEY, Sean E, CARDINAL-DAVID, Benoit, ENRIGHT, Brian P, KLIX, Russell C, LAO, Yanbin, LOU, Xiaochun, MATULENKO, Mark A, STELLA, Valentino J, HO, Raimundo, WANG, Zhi, STAMBULI, James, CHAN, Vincent S, VOIGHT, Eric A
• Format: Patent
• Language: English; French; German
• Published: 31.05.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dop...