PARA-AMINO-BENZYL LINKERS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN CONJUGATES
The present invention relates to para-amino-benzyl linker compounds useful for linking drug moieties to antibodies, to linker-drug compounds in which said para-amino-benzyl linker compounds are covalently linked to drug moieties, and to antibody-drug conjugates in which said para-amino-benzyl linker...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English French German |
| Published |
29.03.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to para-amino-benzyl linker compounds useful for linking drug moieties to antibodies, to linker-drug compounds in which said para-amino-benzyl linker compounds are covalently linked to drug moieties, and to antibody-drug conjugates in which said para-amino-benzyl linker compounds are covalently linked to drug wherein said drug is enzymatically cleaved from the conjugate at a particular cell or tissue type targeted by said antibody. |
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| AbstractList | The present invention relates to para-amino-benzyl linker compounds useful for linking drug moieties to antibodies, to linker-drug compounds in which said para-amino-benzyl linker compounds are covalently linked to drug moieties, and to antibody-drug conjugates in which said para-amino-benzyl linker compounds are covalently linked to drug wherein said drug is enzymatically cleaved from the conjugate at a particular cell or tissue type targeted by said antibody. |
| Author | KOSTOVA, Vesela FRANZETTI, Georges-Alain STARCK, Jérôme-Benoît DESOS, Patrice |
| Author_xml | – fullname: FRANZETTI, Georges-Alain – fullname: DESOS, Patrice – fullname: STARCK, Jérôme-Benoît – fullname: KOSTOVA, Vesela |
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| DocumentTitleAlternate | LIEURS PARA-AMINO-BENZYLE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION DANS DES CONJUGUÉS PARA-AMINO-BENZYL-LINKER, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG IN KONJUGATEN |
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| Snippet | The present invention relates to para-amino-benzyl linker compounds useful for linking drug moieties to antibodies, to linker-drug compounds in which said... |
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| Title | PARA-AMINO-BENZYL LINKERS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN CONJUGATES |
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