COMPOSITIONS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND OTHER NEURODEGENERATIVE DISEASES
The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and compositions related thereto. Described herein are in vitro (cell culture) and in vivo (animal model) experimental examples demonstrating mitochond...
Saved in:
Main Authors | , , |
---|---|
Format | Patent |
Language | English French German |
Published |
01.05.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and compositions related thereto. Described herein are in vitro (cell culture) and in vivo (animal model) experimental examples demonstrating mitochondrial organelle transplantation (MOT) for the treatment of NDs such as amyotrophic lateral sclerosis (ALS). Furthermore, as discussed herein, MOT has been performed in five human ALS patients with positive results-measurable improvement of their conditions has been observed, with no adverse events. |
---|---|
AbstractList | The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and compositions related thereto. Described herein are in vitro (cell culture) and in vivo (animal model) experimental examples demonstrating mitochondrial organelle transplantation (MOT) for the treatment of NDs such as amyotrophic lateral sclerosis (ALS). Furthermore, as discussed herein, MOT has been performed in five human ALS patients with positive results-measurable improvement of their conditions has been observed, with no adverse events. |
Author | ELLIOTT, Robert L JIANG, Xianpeng SEGAL, Brent M |
Author_xml | – fullname: ELLIOTT, Robert L – fullname: JIANG, Xianpeng – fullname: SEGAL, Brent M |
BookMark | eNqNjLsKwkAQAFNo4esfttRCEIwYy-Nu4x0kt-F2FaxCkLOSJBj_H4P4AVbTzMw8mbRdG2fJS1NZETtx5BmUN1CiWDIMOQWQgEpK9AKUgypvJIEq6zQUSjCoAlgXGMacYa0K3nwHJBYDeLwEMnhGP4rirgjGMSpGXibTR_Mc4urHRQI5irbb2Hd1HPrmHtv4rrFKd9nxkJ1Uuv9D-QBqPDoT |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON AMYOTROPHER LATERALSKLEROSE (ALS) UND ANDEREN NEURODEGENERATIVEN ERKRANKUNGEN COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE (SLA) ET D'AUTRES MALADIES NEURODÉGÉNÉRATIVES |
ExternalDocumentID | EP4087589A4 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_EP4087589A43 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 12:50:50 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English French German |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_EP4087589A43 |
Notes | Application Number: EP20200912639 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240501&DB=EPODOC&CC=EP&NR=4087589A4 |
ParticipantIDs | epo_espacenet_EP4087589A4 |
PublicationCentury | 2000 |
PublicationDate | 20240501 |
PublicationDateYYYYMMDD | 2024-05-01 |
PublicationDate_xml | – month: 05 year: 2024 text: 20240501 day: 01 |
PublicationDecade | 2020 |
PublicationYear | 2024 |
RelatedCompanies | The Sallie Astor Burdine Breast Foundation |
RelatedCompanies_xml | – name: The Sallie Astor Burdine Breast Foundation |
Score | 3.5436988 |
Snippet | The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | COMPOSITIONS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND OTHER NEURODEGENERATIVE DISEASES |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240501&DB=EPODOC&locale=&CC=EP&NR=4087589A4 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NS8MwFA9zinrTqTi_yEGGHoZs_Vh3GNI1Ka2sTWnjmKextins0o2t4r_vS_ahF72Fhj6aB--9_NLf-wWhR2PW6-d9YbVNIUx5dNNtwy7BaluFVuii6KSpImMGoem9628TY1JD810vjNIJ_VLiiBBRGcR7pfL18ucQiyhu5folncOjxavLB6S1RcdQngzAxmQ4oBEjzGk5DoxaYTzQpXK71bf1A3Qod9FSZp-Oh7IpZfm7orhn6CgCY2V1jmqibKATZ3fxWgMdB9v_3TDcht76Aq0cFkQs8VXbL7ZDggPKPUYSDDgO85jaXOryY-ZiO_hgPGaR5zt4ZHNJTcNScSOG1xP8ZI-SZ2WAcY_GOJRkPkI3HDbujykmfkJtyLOXCLuUO14bPn66d9SURvtlaleoXi5KcY1wnvWybsfsZnoBWCsHzJJ1tFwTmWbMLMtIm6j5p5mbf-Zu0an0-Ib9d4fq1epT3EOFrtIH5dtvZZ2Mvw |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3PT4MwFG7mNM6bTo3zZw9m0QMxG7Cxw2IYLQEFSqAueloGlGQXtmwY_30f3Q-96K1pw0v7ktfXr_3eB0L3-rQ_yAbCUHpC9Kqrm64CpwRDMXI110TeSRJJxvSDnvOmvbzr7zU029bCSJ3QLymOCBGVQryXcr9e_FxiEcmtXD0lM-iaP9t8SNobdAzpSQdsTEZDGjLCrLZlQasdREOtUm43Bqa2h_b7gAglUhqPqqKUxe-MYh-jgxCMFeUJqomiiRrW9sdrTXTob967obkJvdUpWlrMD1nsyrJfbAYE-5Q7jMQYcBzmETV5pcuPmY1N_4PxiIWOa2HP5BU1DVeKGxF8HuMH04sfpQHGHRrhoCLzEbrmsHF3TDFxY2rCPnuGsE255Sgw-cnOURMa7papnqN6MS_EBcJZ2k-7nV431XLAWhlglrSjZqpIVX1qGHrSQq0_zVz-M3aHGg73vYnnBq9X6Kjy_poJeI3q5fJT3EC2LpNb6edvH-6PqQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=COMPOSITIONS+AND+METHODS+FOR+TREATMENT+OF+AMYOTROPHIC+LATERAL+SCLEROSIS+%28ALS%29+AND+OTHER+NEURODEGENERATIVE+DISEASES&rft.inventor=ELLIOTT%2C+Robert+L&rft.inventor=JIANG%2C+Xianpeng&rft.inventor=SEGAL%2C+Brent+M&rft.date=2024-05-01&rft.externalDBID=A4&rft.externalDocID=EP4087589A4 |