COMPOSITIONS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND OTHER NEURODEGENERATIVE DISEASES
The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and compositions related thereto. Described herein are in vitro (cell culture) and in vivo (animal model) experimental examples demonstrating mitochond...
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| Format | Patent |
| Language | English French German |
| Published |
01.05.2024
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| Abstract | The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and compositions related thereto. Described herein are in vitro (cell culture) and in vivo (animal model) experimental examples demonstrating mitochondrial organelle transplantation (MOT) for the treatment of NDs such as amyotrophic lateral sclerosis (ALS). Furthermore, as discussed herein, MOT has been performed in five human ALS patients with positive results-measurable improvement of their conditions has been observed, with no adverse events. |
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| AbstractList | The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and compositions related thereto. Described herein are in vitro (cell culture) and in vivo (animal model) experimental examples demonstrating mitochondrial organelle transplantation (MOT) for the treatment of NDs such as amyotrophic lateral sclerosis (ALS). Furthermore, as discussed herein, MOT has been performed in five human ALS patients with positive results-measurable improvement of their conditions has been observed, with no adverse events. |
| Author | ELLIOTT, Robert L JIANG, Xianpeng SEGAL, Brent M |
| Author_xml | – fullname: ELLIOTT, Robert L – fullname: JIANG, Xianpeng – fullname: SEGAL, Brent M |
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| DocumentTitleAlternate | ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON AMYOTROPHER LATERALSKLEROSE (ALS) UND ANDEREN NEURODEGENERATIVEN ERKRANKUNGEN COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE (SLA) ET D'AUTRES MALADIES NEURODÉGÉNÉRATIVES |
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| Notes | Application Number: EP20200912639 |
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| Snippet | The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and... |
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| Title | COMPOSITIONS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND OTHER NEURODEGENERATIVE DISEASES |
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