OGA INHIBITOR COMPOUNDS
The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatmen...
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| Main Authors | , , , , , , , , |
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| Format | Patent |
| Language | English French German |
| Published |
26.10.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations. |
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| AbstractList | The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations. |
| Author | MARTINEZ LAMENCA, Carolina BARTOLOMÉ-NEBREDA, José Manuel BUIJNSTERS, Petrus Jacobus Johannes Antonius DE LUCAS OLIVARES, Ana Isabel VAN ROOSBROECK, Yves Emiel M LEENAERTS, Joseph Elisabeth TRABANCO-SUÁREZ, Andrés, Avelino OEHLRICH, Daniel VELTER, Adriana Ingrid |
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| DocumentTitleAlternate | COMPOSÉS INHIBITEURS D'OGA OGA-INHIBITOR-VERBINDUNGEN |
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| Notes | Application Number: EP20200838041 |
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| RelatedCompanies | Janssen Pharmaceutica NV |
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| Snippet | The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds,... |
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| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | OGA INHIBITOR COMPOUNDS |
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