THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF
Provided herein are compounds comprising a four-ring core, such as compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Also provided herein are methods of inhibiting a component of the sterol regulatory element binding...
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| Main Authors | , |
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| Format | Patent |
| Language | English French German |
| Published |
21.09.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Provided herein are compounds comprising a four-ring core, such as compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Also provided herein are methods of inhibiting a component of the sterol regulatory element binding protein (SREBP) pathway, such as an SREBP or SREBP cleavage activating protein (SCAP), using these compounds, or pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Further provided are methods of treating a disorder in a subject in need thereof, such as liver disease, non-alcoholic steatohepatitis, insulin resistance, or cancer. |
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| AbstractList | Provided herein are compounds comprising a four-ring core, such as compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Also provided herein are methods of inhibiting a component of the sterol regulatory element binding protein (SREBP) pathway, such as an SREBP or SREBP cleavage activating protein (SCAP), using these compounds, or pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Further provided are methods of treating a disorder in a subject in need thereof, such as liver disease, non-alcoholic steatohepatitis, insulin resistance, or cancer. |
| Author | HART, Barry Patrick GREEN, Michael John |
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| DocumentTitleAlternate | THIOPHENVERBINDUNGEN MIT CYCLISCHEN AMIDEN UND DEREN VERWENDUNGEN COMPOSÉS THIOPHÈNE AYANT DES AMIDES CYCLIQUES, ET LEURS UTILISATIONS |
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| Notes | Application Number: EP20200888394 |
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| PublicationYear | 2022 |
| RelatedCompanies | Capulus Therapeutics, LLC |
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| Snippet | Provided herein are compounds comprising a four-ring core, such as compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates,... |
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| Title | THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF |
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