COMPOSITION, COMPRISING TMEM176B OR AN EXPRESSION OR ACTIVITY REGULATOR THEREOF AS AN ACTIVE INGREDIENT, FOR PREVENTION OR TREATMENT OF DEGENERATIVE BRAIN DISEASE
Provided is a composition for prophylaxis or treatment of neurodegenerative brain disease, the composition including TMEM176B as an active ingredient. The composition according to an aspect not only promotes phagocytosis of amyloid-beta in astrocytes and reduces amyloid plaques, but also exhibits an...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English French German |
| Published |
23.11.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Provided is a composition for prophylaxis or treatment of neurodegenerative brain disease, the composition including TMEM176B as an active ingredient. The composition according to an aspect not only promotes phagocytosis of amyloid-beta in astrocytes and reduces amyloid plaques, but also exhibits an effect of ameliorating behavior and cognitive functions in an animal model having Alzheimer's disease. Therefore, the composition can be usefully utilized for the prophylaxis and/or treatment of various neurodegenerative brain diseases. |
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| AbstractList | Provided is a composition for prophylaxis or treatment of neurodegenerative brain disease, the composition including TMEM176B as an active ingredient. The composition according to an aspect not only promotes phagocytosis of amyloid-beta in astrocytes and reduces amyloid plaques, but also exhibits an effect of ameliorating behavior and cognitive functions in an animal model having Alzheimer's disease. Therefore, the composition can be usefully utilized for the prophylaxis and/or treatment of various neurodegenerative brain diseases. |
| Author | KIM, Junghwan KIM, Hye-Ju PARK, Seongjeong PARK, Sanghoon |
| Author_xml | – fullname: PARK, Sanghoon – fullname: PARK, Seongjeong – fullname: KIM, Hye-Ju – fullname: KIM, Junghwan |
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| DocumentTitleAlternate | COMPOSITION, COMPRENANT DU TMEM176B, OU UN RÉGULATEUR D'EXPRESSION OU D'ACTIVITÉ ASSOCIÉ, UTILISÉ COMME PRINCIPE ACTIF, POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE MALADIE DÉGÉNÉRATIVE DU CERVEAU ZUSAMMENSETZUNG MIT TMEM176B ODER EINEM EXPRESSIONS- ODER AKTIVITÄTSREGULATOR DAVON ALS WIRKSTOFF, ZUR VORBEUGUNG ODER BEHANDLUNG VON DEGENERATIVER GEHIRNERKRANKUNG |
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| Notes | Application Number: EP20200885467 |
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| RelatedCompanies | Amyloid Solution Inc |
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| Snippet | Provided is a composition for prophylaxis or treatment of neurodegenerative brain disease, the composition including TMEM176B as an active ingredient. The... |
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| Title | COMPOSITION, COMPRISING TMEM176B OR AN EXPRESSION OR ACTIVITY REGULATOR THEREOF AS AN ACTIVE INGREDIENT, FOR PREVENTION OR TREATMENT OF DEGENERATIVE BRAIN DISEASE |
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