STAPHYLOCOCCUS PEPTIDES AND METHODS OF USE

Provided herein are immunogenic compositions comprising a Staphylococcus aureus protein A (SpA) variant and a mutant staphylococcal leukocidin subunit polypeptide comprising a LukA polypeptide, a LukB polypeptide, and/or a LukAB dimer polypeptide, wherein the LukA polypeptide, the LukB polypeptide,...

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Main Authors KIM, Hwan Keun, SHI, Miaomiao, FERNANDEZ, Jeffrey A, POOLMAN, Jan Theunis, MISSIAKAS, Dominique, SUN, Yan, CHEN, Xinhai, SCHNEEWIND, Olaf
Format Patent
LanguageEnglish
French
German
Published 10.08.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein are immunogenic compositions comprising a Staphylococcus aureus protein A (SpA) variant and a mutant staphylococcal leukocidin subunit polypeptide comprising a LukA polypeptide, a LukB polypeptide, and/or a LukAB dimer polypeptide, wherein the LukA polypeptide, the LukB polypeptide, and/or the LukAB dimer polypeptide have one or more amino acid substitutions, deletions, or a combination thereof.
Bibliography:Application Number: EP20200800380