METHODS FOR RECOVERING MEVALONIC ACID OR SALTS OR LACTONES THEREOF FROM AQUEOUS SOLUTIONS USING WATER SOLVENT CRYSTALLIZATION AND COMPOSITIONS THEREOF

• Main Authors: NURMI, Juha, WHITED, Gregory M, JÄRVINEN, Juho, KOIVIKKO, Hannu, MENTUNEN, Tero Tuomas, KUUSISTO, Jyrki, SÄRELÄ, Pertti Matias, SIITONEN, Jani
• Format: Patent
• Language: English; French; German
• Published: 06.07.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SEPARATION; THEIR RELEVANT APPARATUS; TRANSPORTING

Compositions and methods are provided for producing crystalline forms of organic acids or salts or lactones thereof from an aqueous solution. More specifically, methods are provided for producing a crystalline form of a salt of mevalonic acid (also referred to as X-MVA) from an aqueous solution, comprising subjecting the aqueous solution comprising said X-MVA to a purification step to produce a purified solution and crystallizing said X-MVA from said purified solution by water solvent crystallization. Methods are also provided for producing mevalonolactone from an aqueous solution comprising X-MVA, comprising subjecting the aqueous solution comprising said X-MVA to cation exchange thereby converting said aqueous solution comprising X-MVA to an aqueous solution comprising mevalonolactone (MVL). Methods are also provided for producing mevalonolactone monohydrate crystals.