ANTIBODY EPITOPE

• Main Authors: LAWSON, Alastair, LIGHTWOOD, Daniel John, O'CONNELL, James Philip, PORTER, John Robert, WOOTTON, Rebecca Jayne, ARAKAKI, Tracy Lynn
• Format: Patent
• Language: English; French; German
• Published: 27.04.2022
• Subjects: CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; TESTING

It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compoun...