NOVEL FORMULATIONS AND USES FOR CURCUMA EXTRACTS

• Main Authors: WOLDEMARIAM, Tibebe, PATHER, Indiran
• Format: Patent
• Language: English; French; German
• Published: 13.04.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

A method of preparing a formulation having a pharmaceutically acceptable liquid extract of Curcuma longa L, the method comprising:macerating at least a portion of a Curcuma longa L. root for an effective time in an at least substantially non-toxic extraction solvent that is miscible with phenolic diketones that include curcumin, demethoxycurcumin, and bisdemethoxycurcumin; and,pharmaceutically acceptable as a carrier for the phenolic diketones, the carrier having an acute oral toxicity with an LD50 of at least 49,700 mg/kg;wherein, the macerating includes covering the portion of the Curcuma longa L. root with the extraction solvent;separating the extraction solvent from the macerated Curcuma longa L. root to create a liquid extract of Curcuma longa L, the extract including curcumin; and,incorporating the liquid extract directly into the formulation without removal of the extraction solvent, the carrier having the acute oral toxicity with the LD50 of at least 49,700 mg/kg which is at least substantially less toxic than ethanol;wherein, the extraction solvent is selected from the group consisting of sesame oil, liquid paraffin, glycerin, squalene, cotton seed oil, liquid-grade polyethylene glycol, isopropyl myristate, polysorbate 80, and combinations thereof.