BRYOSTATIN COMPOUNDS FOR ENHANCEMENT OF IMMUNOTHERAPY
Provided herein is the use of bryostatin agents to selectively enhance expression, translocation and/or cell surface presentation of an antigen in target cells of interest to modulate immunogenicity of the target cells. Aspects of the methods include, administering an effective amount of a bryostati...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
21.06.2023
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Abstract | Provided herein is the use of bryostatin agents to selectively enhance expression, translocation and/or cell surface presentation of an antigen in target cells of interest to modulate immunogenicity of the target cells. Aspects of the methods include, administering an effective amount of a bryostatin agent to a subject to modulate immunogenicity of target cells. The subject methods include a method of treating cancer, including administering to a subject an effective amount of a bryostatin agent to enhance cell surface antigen or neoantigen presentation on target cells of the subject, and administering to the subject a therapeutically effective amount of a therapeutic agent that specifically binds the cell surface antigen to treat the subject for cancer. Aspects of the subject methods also include use of the bryostatin agents to sensitize the target cells to clearance by the subject's immune system. |
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AbstractList | Provided herein is the use of bryostatin agents to selectively enhance expression, translocation and/or cell surface presentation of an antigen in target cells of interest to modulate immunogenicity of the target cells. Aspects of the methods include, administering an effective amount of a bryostatin agent to a subject to modulate immunogenicity of target cells. The subject methods include a method of treating cancer, including administering to a subject an effective amount of a bryostatin agent to enhance cell surface antigen or neoantigen presentation on target cells of the subject, and administering to the subject a therapeutically effective amount of a therapeutic agent that specifically binds the cell surface antigen to treat the subject for cancer. Aspects of the subject methods also include use of the bryostatin agents to sensitize the target cells to clearance by the subject's immune system. |
Author | WENDER, Paul SHIMIZU, Akira J HARDMAN, Clayton |
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DocumentTitleAlternate | COMPOSÉS DE BRYOSTATINE POUR L'AMÉLIORATION DE L'IMMUNOTHÉRAPIE BRYOSTATINVERBINDUNGEN ZUR VERBESSERUNG DER IMMUNTHERAPIE |
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RelatedCompanies | The Board Of Trustees Of The Leland Stanford Junior University |
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Title | BRYOSTATIN COMPOUNDS FOR ENHANCEMENT OF IMMUNOTHERAPY |
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