MODULATING ANTIBODY EFFECTOR FUNCTIONS
Provided herein are methods of modulating Fc gamma Receptor (FcγR)-mediated cytotoxicity of an antibody composition. In exemplary embodiments, the method comprises (1) increasing or decreasing the amount of terminal β-galactose at the N-297 glycosylation site of panitumumab, or increasing or decreas...
Saved in:
| Main Authors | , , , |
|---|---|
| Format | Patent |
| Language | English French German |
| Published |
16.03.2022
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Provided herein are methods of modulating Fc gamma Receptor (FcγR)-mediated cytotoxicity of an antibody composition. In exemplary embodiments, the method comprises (1) increasing or decreasing the amount of terminal β-galactose at the N-297 glycosylation site of panitumumab, or increasing or decreasing the amount of panitumumab molecules that comprise G1, G1a, G1b and/or G2 galactosylated glycan at the N-297 site, (2) increasing or decreasing the amount of panitumumab molecules that comprise fucosylated glycan at the N-297 site, or increasing or decreasing the amount of panitumumab molecules that comprise afucosylated glycan at the N-297 site, and (3) increasing or decreasing the amount of panitumumab molecules that comprise a high-mannose glycan at the N-297 site. |
|---|---|
| AbstractList | Provided herein are methods of modulating Fc gamma Receptor (FcγR)-mediated cytotoxicity of an antibody composition. In exemplary embodiments, the method comprises (1) increasing or decreasing the amount of terminal β-galactose at the N-297 glycosylation site of panitumumab, or increasing or decreasing the amount of panitumumab molecules that comprise G1, G1a, G1b and/or G2 galactosylated glycan at the N-297 site, (2) increasing or decreasing the amount of panitumumab molecules that comprise fucosylated glycan at the N-297 site, or increasing or decreasing the amount of panitumumab molecules that comprise afucosylated glycan at the N-297 site, and (3) increasing or decreasing the amount of panitumumab molecules that comprise a high-mannose glycan at the N-297 site. |
| Author | PADAKI, Rupa KUHNS, Scott Thomas BRETZLAFF, William S ZHANG, Qingchun |
| Author_xml | – fullname: PADAKI, Rupa – fullname: BRETZLAFF, William S – fullname: ZHANG, Qingchun – fullname: KUHNS, Scott Thomas |
| BookMark | eNrjYmDJy89L5WRQ8_V3CfVxDPH0c1dw9AvxdPJ3iVRwdXNzdQ7xD1JwC_VzDvH09wvmYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgHGlmZmRiZmjobGRCgBAHmFJTA |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | MODULATION VON ANTIKÖRPER-EFFEKTORFUNKTIONEN MODULATION DE FONCTIONS EFFECTRICES D'ANTICORPS |
| ExternalDocumentID | EP3966246A1 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_EP3966246A13 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 13:10:34 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English French German |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_EP3966246A13 |
| Notes | Application Number: EP20200746342 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220316&DB=EPODOC&CC=EP&NR=3966246A1 |
| ParticipantIDs | epo_espacenet_EP3966246A1 |
| PublicationCentury | 2000 |
| PublicationDate | 20220316 |
| PublicationDateYYYYMMDD | 2022-03-16 |
| PublicationDate_xml | – month: 03 year: 2022 text: 20220316 day: 16 |
| PublicationDecade | 2020 |
| PublicationYear | 2022 |
| RelatedCompanies | Amgen, Inc |
| RelatedCompanies_xml | – name: Amgen, Inc |
| Score | 3.3827553 |
| Snippet | Provided herein are methods of modulating Fc gamma Receptor (FcγR)-mediated cytotoxicity of an antibody composition. In exemplary embodiments, the method... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| Title | MODULATING ANTIBODY EFFECTOR FUNCTIONS |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220316&DB=EPODOC&locale=&CC=EP&NR=3966246A1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8MwDLamgYAbDBDjpR5QbxVbm3bdoUJt0rIh-tBo0ThNbdpKu4yJFfH3caJucIGblUhOYuWL7cR2AO64iV4yKW2NFMVYI-XA1HLbqDVe5pZZj4a8zkWCcxhZk4w8zc15B5bbXBhZJ_RLFkdERHHEeyPP6_XPJRaTsZWb-2KJTe8PQeowtfWOdR33qKUyz_GTmMVUpRQpNZo5Bpr1OrFcdJT20IoeCTD4r55ISln_1ijBMewnyGzVnECnWvXgkG4_XuvBQdi-dyPZQm9zCmoYs-zZTafRo-JG6dSL2ZuCVqZP03imBFkko0FezkAJ_JRONBxwsVvcwk92UzPOoYs-f3UBysAubFErrualTXiFSp3rKL1qXBMiKtr0of8nm8t_-q7gSEhJBFENrWvoNh-f1Q1q1aa4lfL4BjaCeFE |
| link.rule.ids | 230,309,783,888,25576,76882 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8MwDLamgRg3GCDGswfUW8XWpl13qFCftNCXRovGqWrTVtplTKyIv49TdYML3KJEchIrju3E_gxwR2X0kkmpCqQoZgIpx7KQq1It0DJX5Ho6oXXOEpyDUHFT8rSQFz1YbnNhWpzQrxYcESWKorw37X29_nnEstrYys19scSu9wcn0Sy-845FEc-owluGZseRFZm8aWKLD-eahGa9SBQdHaU9tLBVVuzAfjVYUsr6t0ZxjmA_RmKr5hh61WoIA3NbeG0IB0H3343NTvQ2J8AHkZX6euKFj5weJp4RWW8cWpm2mURzzknDNhrk5RQ4x05MV8AJs93mMjveLU06gz76_NU5cGO1UBlWXE1LldAKlToVkXvVrCaEIdqMYPQnmYt_xm5h4CaBn_le-HwJh4xjLKBqolxBv_n4rK5RwzbFTcubbwJee0E |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=MODULATING+ANTIBODY+EFFECTOR+FUNCTIONS&rft.inventor=PADAKI%2C+Rupa&rft.inventor=BRETZLAFF%2C+William+S&rft.inventor=ZHANG%2C+Qingchun&rft.inventor=KUHNS%2C+Scott+Thomas&rft.date=2022-03-16&rft.externalDBID=A1&rft.externalDocID=EP3966246A1 |