METHOD FOR PURIFYING FC REGION-MODIFIED ANTIBODY

The present inventors discovered affinity purification resins having sufficient binding affinity for Fc region variants with reduced binding to Protein A. Specifically, immunoglobulins containing an Fc region variant having reduced binding to Protein A could be purified using a Protein A-modified li...

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Main Authors FUKUNAGA, Masahiro, WAKABAYASHI, Tetsuya, SHIMIZU, Yuichiro, MAJIMA, Eiji
Format Patent
LanguageEnglish
French
German
Published 16.02.2022
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract The present inventors discovered affinity purification resins having sufficient binding affinity for Fc region variants with reduced binding to Protein A. Specifically, immunoglobulins containing an Fc region variant having reduced binding to Protein A could be purified using a Protein A-modified ligand containing a structure in which the amino acids of the C-domain have been substituted as an Fc ligand.
AbstractList The present inventors discovered affinity purification resins having sufficient binding affinity for Fc region variants with reduced binding to Protein A. Specifically, immunoglobulins containing an Fc region variant having reduced binding to Protein A could be purified using a Protein A-modified ligand containing a structure in which the amino acids of the C-domain have been substituted as an Fc ligand.
Author FUKUNAGA, Masahiro
SHIMIZU, Yuichiro
WAKABAYASHI, Tetsuya
MAJIMA, Eiji
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DocumentTitleAlternate VERFAHREN ZUR REINIGUNG VON FC-REGION-MODIFIZIERTEM ANTIKÖRPER
PROCÉDÉ DE PURIFICATION D'ANTICORPS MODIFIÉ EN RÉGION FC
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Snippet The present inventors discovered affinity purification resins having sufficient binding affinity for Fc region variants with reduced binding to Protein A....
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METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title METHOD FOR PURIFYING FC REGION-MODIFIED ANTIBODY
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