CLARIFICATION SETUP OF A BIOPROCESSING INSTALLATION
The invention is directed to a clarification setup of a bioprocessing installation for the clarification of a cell broth by centrifugation and subsequent filtration, wherein, for the centrifugation, the clarification setup comprises a centrifuge (1), wherein the centrifuge (1) comprises at least one...
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Format | Patent |
Language | English French German |
Published |
12.01.2022
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Subjects | |
Online Access | Get full text |
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Abstract | The invention is directed to a clarification setup of a bioprocessing installation for the clarification of a cell broth by centrifugation and subsequent filtration, wherein, for the centrifugation, the clarification setup comprises a centrifuge (1), wherein the centrifuge (1) comprises at least one centrifuge chamber (2) with a chamber inlet (3) and a chamber outlet (4), wherein the clarification setup comprises a liquid pumping arrangement (5) assigned to the centrifuge (1) and a liquid network (6) with a number of liquid lines (7) communicating with the liquid pumping arrangement (5), wherein the clarification setup comprises a process control (8) for controlling at least the centrifuge (1) and the liquid pumping arrangement (5). It is proposed that for filtration, the clarification setup comprises a filter arrangement (9), that the liquid network (6) provides an outlet supernatant line (10) for a liquid connection between the chamber outlet (4) and the filter arrangement (9), which is at least temporarily, preferably permanently, liquid-tight, such that due to this liquid-tight condition of the outlet supernatant line (10) the liquid pumping arrangement (5) as such may drive the supernatant from the chamber outlet (4) to the filter arrangement (9) via the outlet supernatant line (10). |
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AbstractList | The invention is directed to a clarification setup of a bioprocessing installation for the clarification of a cell broth by centrifugation and subsequent filtration, wherein, for the centrifugation, the clarification setup comprises a centrifuge (1), wherein the centrifuge (1) comprises at least one centrifuge chamber (2) with a chamber inlet (3) and a chamber outlet (4), wherein the clarification setup comprises a liquid pumping arrangement (5) assigned to the centrifuge (1) and a liquid network (6) with a number of liquid lines (7) communicating with the liquid pumping arrangement (5), wherein the clarification setup comprises a process control (8) for controlling at least the centrifuge (1) and the liquid pumping arrangement (5). It is proposed that for filtration, the clarification setup comprises a filter arrangement (9), that the liquid network (6) provides an outlet supernatant line (10) for a liquid connection between the chamber outlet (4) and the filter arrangement (9), which is at least temporarily, preferably permanently, liquid-tight, such that due to this liquid-tight condition of the outlet supernatant line (10) the liquid pumping arrangement (5) as such may drive the supernatant from the chamber outlet (4) to the filter arrangement (9) via the outlet supernatant line (10). |
Author | SABALLUS, Martin |
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DocumentTitleAlternate | KLÄRUNGSEINRICHTUNG EINER BIOVERARBEITUNGSANLAGE CONFIGURATION DE CLARIFICATION D'UNE INSTALLATION DE BIOTRAITEMENT |
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RelatedCompanies | Sartorius Stedim Biotech GmbH |
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Snippet | The invention is directed to a clarification setup of a bioprocessing installation for the clarification of a cell broth by centrifugation and subsequent... |
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SubjectTerms | APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE |
Title | CLARIFICATION SETUP OF A BIOPROCESSING INSTALLATION |
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