METHOD FOR PREPARING DRUG TOXIN PNU-159682 OF ANTIBODY DRUG CONJUGATE, AND INTERMEDIATE THEREIN

The disclosure provides a method for preparing drug toxin PNU-159682 (morpholinyl anthracycline derivative) for antibody-conjugated drugs and intermediates involved in the preparation method. The preparation method of the present disclosure improves the stability, practicability and scalability of t...

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Main Authors GUI, Dong, LI, Hui, KONG, Lingpei, ZHANG, Binbin, CHEN, Yu, JIA, Zhongquan, XIA, Deyin, GUO, Maojun, LI, Haihong
Format Patent
LanguageEnglish
French
German
Published 10.11.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract The disclosure provides a method for preparing drug toxin PNU-159682 (morpholinyl anthracycline derivative) for antibody-conjugated drugs and intermediates involved in the preparation method. The preparation method of the present disclosure improves the stability, practicability and scalability of the process by introducing protecting groups and changing to reagents that are capable to amplify; the preparation method of the present disclosure minimizes the risk and operational difficulty during scale-up production; production and operation is simple and convenient.
AbstractList The disclosure provides a method for preparing drug toxin PNU-159682 (morpholinyl anthracycline derivative) for antibody-conjugated drugs and intermediates involved in the preparation method. The preparation method of the present disclosure improves the stability, practicability and scalability of the process by introducing protecting groups and changing to reagents that are capable to amplify; the preparation method of the present disclosure minimizes the risk and operational difficulty during scale-up production; production and operation is simple and convenient.
Author LI, Haihong
KONG, Lingpei
CHEN, Yu
XIA, Deyin
GUO, Maojun
JIA, Zhongquan
ZHANG, Binbin
LI, Hui
GUI, Dong
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– fullname: XIA, Deyin
– fullname: GUO, Maojun
– fullname: LI, Haihong
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DocumentTitleAlternate PROCÉDÉ DE PRÉPARATION DE LA TOXINE-MÉDICAMENT PNU-159682 D'UN CONJUGUÉ ANTICORPS-MÉDICAMENT, ET INTERMÉDIAIRE SITUÉ À L'INTÉRIEUR
VERFAHREN ZUR HERSTELLUNG DES ARZNEIMITTELTOXINS PNU-159682 EINES ANTIKÖRPERARZNEIMITTELKONJUGATS UND ZWISCHENPRODUKT DAVON
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RelatedCompanies Levena Biopharma Co., Ltd
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Snippet The disclosure provides a method for preparing drug toxin PNU-159682 (morpholinyl anthracycline derivative) for antibody-conjugated drugs and intermediates...
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HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title METHOD FOR PREPARING DRUG TOXIN PNU-159682 OF ANTIBODY DRUG CONJUGATE, AND INTERMEDIATE THEREIN
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