GENETICALLY MODIFIED MICROORGANISM AND METHOD BOTH FOR PRODUCING NICOTINAMIDE DERIVATIVE, AND VECTOR FOR USE IN SAME

• Main Authors: KANOU, Masanobu, NAKAJIMA, Ryota, WATANABE, Hidekazu, ISHII, Jun, KONDO, Akihiko, SHOJI, Shinichiro
• Format: Patent
• Language: English; French; German
• Published: 27.10.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Provided is a technique for synthesizing a nicotinamide derivative (NAm derivative) such as a nicotinamide mononucleotide (NMN) with high efficiency. A genetically modified microorganism is used, which can express, as nicotinamide phosphoribosylt ransferase (NAMPT), NAMPT having a conversion efficie...