PYRIMIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA-1-ANTITRYPSIN DEFICIENCY

• Main Authors: FOX, David John, HUNTINGTON, James Andrew, RAMSDEN, Nigel
• Format: Patent
• Language: English; French; German
• Published: 15.02.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to oxopyrimidinyl-methyl-benzamide derivatives, for example in a pharmaceutically acceptable salt form or crystal form, pharmaceutical compositions comprising the derivatives, and their medical use, in particular for use in the treatment of α1-antitrypsin deficiency (A1AD or AA...