BICYCLIC-FUSED HETEROARYL COMPOUNDS AS IRAK4 MODULATORS

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula IIc to IIi, IIl to IIv or IIx as defined in the claims. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermedia...

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Main Authors ZAPF, Christoph Wolfgang, TRZUPEK, John David, HEPWORTH, David, STROHBACH, Joseph Walter, PAPAIOANNOU, Nikolaos, WRIGHT, Stephen Wayne, LEE, Arthur, LEE, Katherine Lin, LOVERING, Frank Eldridge, MATHIAS, John Paul, HAN, Seungil, ALLAIS, Christophe Philippe, GAVRIN, Lori Krim, OWEN, Dafydd Rhys, DEHNHARDT, Christoph Martin, SAIAH, Eddine
Format Patent
LanguageEnglish
French
German
Published 04.08.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula IIc to IIi, IIl to IIv or IIx as defined in the claims. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Bibliography:Application Number: EP20210157042