ANTI-BCMA SINGLE-CHAIN ANTIBODY SCFV, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

• Main Authors: YANG, Naibo, OUYANG, Bingjie, WANG, Fei, GE, Yuping, REN, Bingzhao, ZHAO, Zhengqi, HOU, Yong, LIU, Yang, LI, Bo, WANG, Meiniang, JIANG, Lin, DONG, Xuan
• Format: Patent
• Language: English; French; German
• Published: 08.12.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided are an anti-BCMA single-chain antibody scFv and a preparation method and application thereof. The preparation method is capable of artificially synthesizing a BCMA-targeted phage display library by combining site-directed mutagenesis and random mutagenesis technologies; and acquiring 3 new-...