PROCESSES FOR PREPARING MEDICAMENTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND INTERMEDIATES FOR USE THEREIN

The present invention provides a process for preparing the (R)-enantiomer (R-N) or the (R)-enantiomer (S-N) of a compound of formula N, the process comprising subjecting a compound of formula M to reduction using a reductase enzymeThe present invention also provides a process for preparing a nitro c...

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Main Authors WEBER, Beat T, RUSSO, Domenico, WAHON, Jorge, PIRES, Rita, MATON, William, SOUSA, Luisa, VASCONCELOS, Téofilo Cardoso de, JERÓNIMO, Paula, LIMA, Ricardo, BARROCAS, Pedro
Format Patent
LanguageEnglish
French
German
Published 21.04.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a process for preparing the (R)-enantiomer (R-N) or the (R)-enantiomer (S-N) of a compound of formula N, the process comprising subjecting a compound of formula M to reduction using a reductase enzymeThe present invention also provides a process for preparing a nitro chromane compound of formula N, the process comprising reacting a nitro chromene compound of formula M with a suitable reducing agent.The present invention also provides a process for preparing the (R)-or (S)-enantiomer of a compound of formula E or a salt thereof
Bibliography:Application Number: EP20200171586