INHIBITORS OF SARM1
The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (...
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Main Authors | , , , , , |
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Format | Patent |
Language | English French German |
Published |
08.12.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARMI). |
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Bibliography: | Application Number: EP20190815890 |