FUSED PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROTIC DISEASES

• Main Authors: COUTY, Sylvain, TIRERA, Amynata, MESIC, Milan, TEMAL-LAIB, Taoues, HECKMANN, Bertrand, ANNOOT, Denis Maurice, RICHARD, Sébastien, TRIBALLEAU, Nicolas
• Format: Patent
• Language: English; French; German
• Published: 24.02.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention discloses compounds according to Formula I:Wherein A, B, R1, R2, and Cy are as defined herein.The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment...