COMPOSITIONS AND METHODS FOR MODULATING LEFT-RIGHT DIFFERENTIATION FACTOR (LEFTY) AND BONE MORPHOGENIC FACTOR (BMP)
This disclosure provides data showing that LEFTY inhibits differentiation-promoting pathways such as BMP7/pSMAD5 in breast cancer cell lines, over and above its known role of inhibiting Nodal/pSMAD2. LEFTY competes with BMP7 to bind to its cell surface receptor BMPR2, leading to inhibition of pSMAD5...
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Main Authors | , , , |
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Format | Patent |
Language | English French German |
Published |
08.06.2022
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Subjects | |
Online Access | Get full text |
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