METHODS AND SYSTEMS FOR OPTIMIZING BUFFER CONDITIONS WITH LIQUID CHROMATOGRAPHY

• Main Authors: BAEK, Jung Un, LIU, Xiaodong, TRACY, Mark Lee, POHL, Christopher A, LIEHR, Shanhua Lin
• Format: Patent
• Language: English; French; German
• Published: 16.12.2020
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

A plurality of chromatograms is run using a salt gradient with a range of constant pH values or using a pH gradient with a range of constant salt concentrations. A chromatography optimization algorithm can be used to identify at least one salt gradient chromatogram or at least one pH gradient chroma...