DEVICES, SYSTEMS, AND METHODS FOR TUMOR VISUALIZATION AND REMOVAL

• Main Authors: ANANTHA, Nayana, Thalanki, LEONG, Wey-Liang, DONE, Susan, Jane, GIBSON, Christopher, OTTOLINO-PERRY, Kathryn, DACOSTA, Ralph, EASSON, Alexandra M
• Format: Patent
• Language: English; French; German
• Published: 20.10.2021
• Subjects: CALCULATING; COMPUTING; COUNTING; DIAGNOSIS; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; IMAGE DATA PROCESSING OR GENERATION, IN GENERAL; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SURGERY

A method of assessing surgical margins is disclosed. The method includes, subsequent to administration of a compound configured to induce emissions of between about 600 nm and about 660 nm in cancerous tissue cells, positioning a distal end of a handheld, white light and fluorescence-based imaging device adjacent to a surgical margin. The method also includes, with the handheld device, substantially simultaneously exciting and detecting autofluorescence emissions of tissue cells and fluorescence emissions of the induced wavelength in tissue cells of the surgical margin. And, based on a presence or an amount of fluorescence emissions of the induced wavelength detected in the tissue cells of the surgical margin, determining whether the surgical margin is substantially free of at least one of precancerous cells, cancerous cells, and satellite lesions. The compound may be a non-activated, non-targeted compound such as ALA.