(2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS

The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including...

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Main Authors CONNOLLY, Stephen, LÖNN, Hans, Roland, AURELL, Carl-Johan, PONTÉN, John Fritiof, WATSON, David Wyn, JONES, Graham Peter, SWALLOW, Steven, VAN DE POËL, Amanda Jane, KARLSSON, Staffan PO, DOYLE, Kevin, James, MACRITCHIE, Jaqueline Anne, PALMER, Nicholas John
Format Patent
LanguageEnglish
French
German
Published 02.12.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
AbstractList The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
Author SWALLOW, Steven
KARLSSON, Staffan PO
LÖNN, Hans, Roland
JONES, Graham Peter
WATSON, David Wyn
CONNOLLY, Stephen
PONTÉN, John Fritiof
VAN DE POËL, Amanda Jane
DOYLE, Kevin, James
AURELL, Carl-Johan
MACRITCHIE, Jaqueline Anne
PALMER, Nicholas John
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– fullname: LÖNN, Hans, Roland
– fullname: AURELL, Carl-Johan
– fullname: PONTÉN, John Fritiof
– fullname: WATSON, David Wyn
– fullname: JONES, Graham Peter
– fullname: SWALLOW, Steven
– fullname: VAN DE POËL, Amanda Jane
– fullname: KARLSSON, Staffan PO
– fullname: DOYLE, Kevin, James
– fullname: MACRITCHIE, Jaqueline Anne
– fullname: PALMER, Nicholas John
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(2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDE ALS DIPEPTIDYL PEPTIDASE I INHIBITOREN
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RelatedCompanies Astrazeneca AB
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Snippet The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable...
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HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS
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