BIVALENT NUCLEIC ACID LIGANDS AND USES THEREFOR

• Main Authors: THADKE, Shivaji, A, PERERA, J. Dinithi R, LY, Danith, H
• Format: Patent
• Language: English; French; German
• Published: 28.10.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Genetic recognition reagents comprising bivalent nucleobases are provided that bind two strands of nucleic acid, such as an expanded repeat sequence associated with an expanded repeat disease. In one example the expanded repeat disease is a polyQ disease, such as Huntington's disease. Methods o...