COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF GENOMIC IMPRINTING

• Main Authors: COTNEY, Justin, CHAMBERLAIN, Stormy, LANGOUET, Maéva, LALANDE, Marc
• Format: Patent
• Language: English; French; German
• Published: 14.10.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Disclosed herein are compositions, kits, and methods for treating a disorder of genomic imprinting in a subject. The method may include modifying a zinc-finger protein 274 (ZNF274) binding site on maternal chromosome 15 at position 15q11-q13 of the subject, such that the binding of a ZNF274 protein...