METHOD OF PURIFYING POLYPEPTIDES

• Main Authors: Smrdelj, Paul, Schroeder, Magnus, Charlton, Adam, Walker, Ian, Napoli, Mark, Stowers, Anthony, Pirzas, Vicky
• Format: Patent
• Language: English; French; German
• Published: 30.09.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an anion-exchange matrix relative to the amount of one or more impurities bound to the anion-exchange matrix. This effect is achieved by adding a...