METHOD FOR PREPARING CHOLIC ACID COMPOUND

The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula I, comprising subjecting a compound of formula 2 to an oxidiza...

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Main Authors CHENG, Xingdong, GAO, Ce, XIA, Chunguang, CHEN, Lang, ZHANG, Xiquan, ZHANG, Aiming
Format Patent
LanguageEnglish
French
German
Published 04.08.2021
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Abstract The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula I, comprising subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I. The preparation method has high yield, requires less purification operations, and is suitable for industrial application.
AbstractList The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula I, comprising subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I. The preparation method has high yield, requires less purification operations, and is suitable for industrial application.
Author CHENG, Xingdong
ZHANG, Xiquan
GAO, Ce
ZHANG, Aiming
CHEN, Lang
XIA, Chunguang
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DocumentTitleAlternate VERFAHREN ZUR HERSTELLUNG EINER CHOLSÄUREVERBINDUNG
PROCÉDÉ DE PRÉPARATION DE COMPOSÉ D'ACIDE CHOLIQUE
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RelatedCompanies Chia Tai Tianqing Pharmaceutical Group Co., Ltd
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Snippet The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the...
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METALLURGY
ORGANIC CHEMISTRY
STEROIDS
Title METHOD FOR PREPARING CHOLIC ACID COMPOUND
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