SPIROCYCLIC INDOLINES AS IL-17 MODULATORS

A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

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Main Authors SELBY, Matthew Duncan, TOWNSEND, Robert James, ZHU, Zhaoning, QUINCEY, Joanna Rachel, BRACE, Gareth Neil, JONES, Elizabeth Pearl, SMALLEY, Adam Peter, FOLEY, Anne Marie, TAYLOR, Richard David, SCHULZE, Monika-Sarah Elisabeth Dorothea, FOULKES, Gregory, CHAPPELL, Rose Elizabeth, DEBOVES, Herv Jean Claude, LECOMTE, Fabien Claude
Format Patent
LanguageEnglish
French
German
Published 10.08.2022
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Abstract A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
AbstractList A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
Author ZHU, Zhaoning
LECOMTE, Fabien Claude
QUINCEY, Joanna Rachel
JONES, Elizabeth Pearl
SCHULZE, Monika-Sarah Elisabeth Dorothea
CHAPPELL, Rose Elizabeth
FOULKES, Gregory
DEBOVES, Herv Jean Claude
BRACE, Gareth Neil
SELBY, Matthew Duncan
TAYLOR, Richard David
SMALLEY, Adam Peter
TOWNSEND, Robert James
FOLEY, Anne Marie
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– fullname: TOWNSEND, Robert James
– fullname: ZHU, Zhaoning
– fullname: QUINCEY, Joanna Rachel
– fullname: BRACE, Gareth Neil
– fullname: JONES, Elizabeth Pearl
– fullname: SMALLEY, Adam Peter
– fullname: FOLEY, Anne Marie
– fullname: TAYLOR, Richard David
– fullname: SCHULZE, Monika-Sarah Elisabeth Dorothea
– fullname: FOULKES, Gregory
– fullname: CHAPPELL, Rose Elizabeth
– fullname: DEBOVES, Herv Jean Claude
– fullname: LECOMTE, Fabien Claude
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DocumentTitleAlternate SPIROCYCLISCHE INDOLINE ALS IL-17-MODULATOREN
INDOLINES SPIROCYCLIQUES UTILISÉES COMME MODULATEURS D'IL-17
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Snippet A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title SPIROCYCLIC INDOLINES AS IL-17 MODULATORS
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