SPIROCYCLIC INDOLINES AS IL-17 MODULATORS

A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

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Bibliographic Details
Main Authors SELBY, Matthew Duncan, TOWNSEND, Robert James, ZHU, Zhaoning, QUINCEY, Joanna Rachel, BRACE, Gareth Neil, JONES, Elizabeth Pearl, SMALLEY, Adam Peter, FOLEY, Anne Marie, TAYLOR, Richard David, SCHULZE, Monika-Sarah Elisabeth Dorothea, FOULKES, Gregory, CHAPPELL, Rose Elizabeth, DEBOVES, Herv Jean Claude, LECOMTE, Fabien Claude
Format Patent
LanguageEnglish
French
German
Published 10.08.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
Bibliography:Application Number: EP20180732703