FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuro...

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Main Authors MACCOSS, Malcolm, ZHU, Zhaoning, HORSLEY, Helen Tracey, HUTCHINGS, Martin Clive, BROOKINGS, Daniel Christopher, JOHNSON, James Andrew, FORICHER, Yann, XUAN, Mengyang, DE HARO GARCIA, Teresa
Format Patent
LanguageEnglish
French
German
Published 15.09.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
AbstractList A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Author JOHNSON, James Andrew
ZHU, Zhaoning
FORICHER, Yann
HORSLEY, Helen Tracey
MACCOSS, Malcolm
BROOKINGS, Daniel Christopher
HUTCHINGS, Martin Clive
XUAN, Mengyang
DE HARO GARCIA, Teresa
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– fullname: BROOKINGS, Daniel Christopher
– fullname: JOHNSON, James Andrew
– fullname: FORICHER, Yann
– fullname: XUAN, Mengyang
– fullname: DE HARO GARCIA, Teresa
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DocumentTitleAlternate KONDENSIERTE PENTACYCLISCHE DERIVATE ALS MODULATOREN DER TNF-AKTIVITÄT
DÉRIVÉS D'IMIDAZOLES PENTACYCLIQUES FUSIONNÉS EN TANT QUE MODULATEURS DE L'ACTIVITÉ DE TNF
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Sanofi
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Snippet A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
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