SUBSTRATES RECOGNIZED BY FIBROBLAST ACTIVATION PROTEIN (FAP) AND METHODS OF USING THE SAME
Fluorescence resonance energy transfer (FRET) constructs comprising donor and acceptor fluorophore moieties, and a peptide linking the two, which is a substrate of the endopeptidase fibroblast activation protein (FAP). Also provided are isolated nucleic acids expressing the construct, cell lines com...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French German |
| Published |
20.01.2021
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| Online Access | Get full text |
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| Abstract | Fluorescence resonance energy transfer (FRET) constructs comprising donor and acceptor fluorophore moieties, and a peptide linking the two, which is a substrate of the endopeptidase fibroblast activation protein (FAP). Also provided are isolated nucleic acids expressing the construct, cell lines comprising the nucleic acids, and kits comprising the construct. Further provided are methods of detecting FAP using the construct via FRET. |
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| AbstractList | Fluorescence resonance energy transfer (FRET) constructs comprising donor and acceptor fluorophore moieties, and a peptide linking the two, which is a substrate of the endopeptidase fibroblast activation protein (FAP). Also provided are isolated nucleic acids expressing the construct, cell lines comprising the nucleic acids, and kits comprising the construct. Further provided are methods of detecting FAP using the construct via FRET. |
| Author | ERNST, James, Andrew SONODA, Junichiro BAINBRIDGE, Travis, William |
| Author_xml | – fullname: SONODA, Junichiro – fullname: ERNST, James, Andrew – fullname: BAINBRIDGE, Travis, William |
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| DocumentTitleAlternate | SUBSTRATS RECONNUS PAR UNE PROTÉINE D'ACTIVATION DES FIBROBLASTES (FAP) ET LEURS MÉTHODES D'UTILISATION DURCH FIBROBLASTENAKTIVIERUNGSPROTEIN (FAP) ERKANNTE SUBSTRATE UND VERFAHREN ZUR VERWENDUNG DAVON |
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| Notes | Application Number: EP20180781501 |
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| RelatedCompanies | F. Hoffmann-La Roche AG |
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| Snippet | Fluorescence resonance energy transfer (FRET) constructs comprising donor and acceptor fluorophore moieties, and a peptide linking the two, which is a... |
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| Title | SUBSTRATES RECOGNIZED BY FIBROBLAST ACTIVATION PROTEIN (FAP) AND METHODS OF USING THE SAME |
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