VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS

The application relates to variants or muteins of tissue inhibitor of metalloproteinase 3 (TIMP-3), especially variants thereof where certain amino acid residues are substituted in order to introduce N-linked glycosylation sites (N-X-T or N-X-S). Some of the variants made improve the half-life and p...

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Bibliographic Details
Main Authors CHINTALGATTU, Vishnu, O'NEILL, Jason C, STEVENS, Jennitte, LeAnn, KET, Randal, R, LEE, Taeweon
Format Patent
LanguageEnglish
French
German
Published 04.12.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The application relates to variants or muteins of tissue inhibitor of metalloproteinase 3 (TIMP-3), especially variants thereof where certain amino acid residues are substituted in order to introduce N-linked glycosylation sites (N-X-T or N-X-S). Some of the variants made improve the half-life and pharmacokinetic or pharmacodynamic properties and facilitate production and purification. In particular, the mutein contain the pairs: K45N/V47T; K50N/V52T; P56N/G58T; H78N/Q80T; K94N/E96T; D110N/K112T; the substitutions R138T; G173T and, optionally, also F57N, leading to at least two engineered N-linked glycosylation sites.
Bibliography:Application Number: EP20190185328