VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
The application relates to variants or muteins of tissue inhibitor of metalloproteinase 3 (TIMP-3), especially variants thereof where certain amino acid residues are substituted in order to introduce N-linked glycosylation sites (N-X-T or N-X-S). Some of the variants made improve the half-life and p...
Saved in:
Main Authors | , , , , |
---|---|
Format | Patent |
Language | English French German |
Published |
04.12.2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The application relates to variants or muteins of tissue inhibitor of metalloproteinase 3 (TIMP-3), especially variants thereof where certain amino acid residues are substituted in order to introduce N-linked glycosylation sites (N-X-T or N-X-S). Some of the variants made improve the half-life and pharmacokinetic or pharmacodynamic properties and facilitate production and purification. In particular, the mutein contain the pairs: K45N/V47T; K50N/V52T; P56N/G58T; H78N/Q80T; K94N/E96T; D110N/K112T; the substitutions R138T; G173T and, optionally, also F57N, leading to at least two engineered N-linked glycosylation sites. |
---|---|
Bibliography: | Application Number: EP20190185328 |