DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES
Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula I.:or a pharmaceutically acceptable salt thereof;wherein:m...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English French German |
| Published |
13.12.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula I.:or a pharmaceutically acceptable salt thereof;wherein:mAb is an anti-CD30 antibody unit,S is a sulfur atom of the antibody,A- is a Stretcher unit, andp is from about 3 to about 5. |
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| AbstractList | Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula I.:or a pharmaceutically acceptable salt thereof;wherein:mAb is an anti-CD30 antibody unit,S is a sulfur atom of the antibody,A- is a Stretcher unit, andp is from about 3 to about 5. |
| Author | SUN, Michael KENNEDY, Dana IHLE, Nathan SIEVERS, Eric |
| Author_xml | – fullname: SUN, Michael – fullname: SIEVERS, Eric – fullname: IHLE, Nathan – fullname: KENNEDY, Dana |
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| DocumentTitleAlternate | RÉGIMES DE DOSAGE POUR CONJUGUÉS DE MÉDICAMENTS-ANTICORPS ANTI-CD30 VC-PAB-MMAE DOSIERUNGSSCHEMATA FÜR ANTI-CD30-VC-PAB-MMAE-ANTIKÖRPER-WIRKSTOFF-KONJUGATE |
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| Notes | Application Number: EP20190159583 |
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| Snippet | Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| Title | DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES |
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