2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH

The present invention provides triazolone compounds of general formula (I):in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds an...

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Main Authors FERRARA, Steven, James, NISING, Carl, Friedrich, GÜNTHER, Judith, EL SHEIKH, Sherif, KRÖBER, Michael, NGUYEN, Duy, STELLFELD, Timo, ZHOU, Han, Jie, CHRISTIAN, Sven, SYKES, David Brian, JANZER, Andreas, ZHAO, Changjia, MUELLER, Thomas, NIEHUES, Michael, ZIMMERMANN, Katja, SCHÄFER, Martina, MERZ, Claudia, GRADL, Stefan, Nikolaus, EIS, Knut, LIU, Kery
Format Patent
LanguageEnglish
French
German
Published 23.03.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention provides triazolone compounds of general formula (I):in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
AbstractList The present invention provides triazolone compounds of general formula (I):in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
Author STELLFELD, Timo
NIEHUES, Michael
SYKES, David Brian
GÜNTHER, Judith
ZHOU, Han, Jie
JANZER, Andreas
EL SHEIKH, Sherif
MERZ, Claudia
GRADL, Stefan, Nikolaus
ZIMMERMANN, Katja
NISING, Carl, Friedrich
EIS, Knut
MUELLER, Thomas
FERRARA, Steven, James
ZHAO, Changjia
LIU, Kery
KRÖBER, Michael
SCHÄFER, Martina
CHRISTIAN, Sven
NGUYEN, Duy
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– fullname: KRÖBER, Michael
– fullname: NGUYEN, Duy
– fullname: STELLFELD, Timo
– fullname: ZHOU, Han, Jie
– fullname: CHRISTIAN, Sven
– fullname: SYKES, David Brian
– fullname: JANZER, Andreas
– fullname: ZHAO, Changjia
– fullname: MUELLER, Thomas
– fullname: NIEHUES, Michael
– fullname: ZIMMERMANN, Katja
– fullname: SCHÄFER, Martina
– fullname: MERZ, Claudia
– fullname: GRADL, Stefan, Nikolaus
– fullname: EIS, Knut
– fullname: LIU, Kery
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DocumentTitleAlternate 2,4,5-TRISUBSTITUIERTE 1,2,4-TRIAZOLONE ALS INHIBITOREN VON DHODH
1,2,4-TRIAZOLONES TRISUBSTITUÉES EN POSITION 2, 4 ET 5, UTILES EN TANT QU'INHIBITEURS DE DHODH
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RelatedCompanies President and Fellows of Harvard College
The General Hospital Corporation
The Broad Institute, Inc
Bayer Aktiengesellschaft
Bayer Pharma Aktiengesellschaft
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Snippet The present invention provides triazolone compounds of general formula (I):in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH
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