LOCKED NUCLEIC ACID CYCLIC DINUCLEOTIDE COMPOUNDS AND USES THEREOF
The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present invention are provided in the form of a composi...
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Format | Patent |
Language | English French German |
Published |
10.07.2019
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Abstract | The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present invention are provided in the form of a composition comprising one or more cyclic dinucleotides that induce human STING-dependent type I interferon production, wherein the cyclic dinucleotides present in the composition have at least one 2′, 4′ locked nucleic acids within the cyclic dinucleotide. |
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AbstractList | The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present invention are provided in the form of a composition comprising one or more cyclic dinucleotides that induce human STING-dependent type I interferon production, wherein the cyclic dinucleotides present in the composition have at least one 2′, 4′ locked nucleic acids within the cyclic dinucleotide. |
Author | TRIA, George, Scott BRUML, Jacob, Robert LE, Thanh Ngoc Lan CANHAM, Stephen NDUBAKU, Chudi, Obioma KANNE, David, Braun MCKENNA, Jeffrey |
Author_xml | – fullname: CANHAM, Stephen – fullname: MCKENNA, Jeffrey – fullname: KANNE, David, Braun – fullname: LE, Thanh Ngoc Lan – fullname: NDUBAKU, Chudi, Obioma – fullname: BRUML, Jacob, Robert – fullname: TRIA, George, Scott |
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DocumentTitleAlternate | CYCLISCHES DINUKLEOTIDVERBINDUNGEN MIT EINGESCHLOSSENEN NUKLEINSÄUREN UND VERWENDUNGEN DAVON COMPOSÉS DINUCLÉOTIDIQUES CYCLIQUES D'ACIDE NUCLÉIQUE BLOQUÉ ET LEURS UTILISATIONS |
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RelatedCompanies | Aduro BioTech, Inc Novartis AG |
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Snippet | The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
Title | LOCKED NUCLEIC ACID CYCLIC DINUCLEOTIDE COMPOUNDS AND USES THEREOF |
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