LOCKED NUCLEIC ACID CYCLIC DINUCLEOTIDE COMPOUNDS AND USES THEREOF

The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present invention are provided in the form of a composi...

Full description

Saved in:
Bibliographic Details
Main Authors CANHAM, Stephen, MCKENNA, Jeffrey, KANNE, David, Braun, LE, Thanh Ngoc Lan, NDUBAKU, Chudi, Obioma, BRUML, Jacob, Robert, TRIA, George, Scott
Format Patent
LanguageEnglish
French
German
Published 10.07.2019
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present invention are provided in the form of a composition comprising one or more cyclic dinucleotides that induce human STING-dependent type I interferon production, wherein the cyclic dinucleotides present in the composition have at least one 2′, 4′ locked nucleic acids within the cyclic dinucleotide.
AbstractList The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present invention are provided in the form of a composition comprising one or more cyclic dinucleotides that induce human STING-dependent type I interferon production, wherein the cyclic dinucleotides present in the composition have at least one 2′, 4′ locked nucleic acids within the cyclic dinucleotide.
Author TRIA, George, Scott
BRUML, Jacob, Robert
LE, Thanh Ngoc Lan
CANHAM, Stephen
NDUBAKU, Chudi, Obioma
KANNE, David, Braun
MCKENNA, Jeffrey
Author_xml – fullname: CANHAM, Stephen
– fullname: MCKENNA, Jeffrey
– fullname: KANNE, David, Braun
– fullname: LE, Thanh Ngoc Lan
– fullname: NDUBAKU, Chudi, Obioma
– fullname: BRUML, Jacob, Robert
– fullname: TRIA, George, Scott
BookMark eNrjYmDJy89L5WRw8vF39nZ1UfALdfZx9XRWcHT2dFFwjnT2AbJdPMGi_iGeLq4Kzv6-Af6hfi7BCo5-Lgqhwa7BCiEerkGu_m48DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTeNcDY1MDc2Mzc0dCYCCUAoQQsWw
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
DocumentTitleAlternate CYCLISCHES DINUKLEOTIDVERBINDUNGEN MIT EINGESCHLOSSENEN NUKLEINSÄUREN UND VERWENDUNGEN DAVON
COMPOSÉS DINUCLÉOTIDIQUES CYCLIQUES D'ACIDE NUCLÉIQUE BLOQUÉ ET LEURS UTILISATIONS
ExternalDocumentID EP3507367A1
GroupedDBID EVB
ID FETCH-epo_espacenet_EP3507367A13
IEDL.DBID EVB
IngestDate Fri Jul 19 16:05:10 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
French
German
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_EP3507367A13
Notes Application Number: EP20170824754
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190710&DB=EPODOC&CC=EP&NR=3507367A1
ParticipantIDs epo_espacenet_EP3507367A1
PublicationCentury 2000
PublicationDate 20190710
PublicationDateYYYYMMDD 2019-07-10
PublicationDate_xml – month: 07
  year: 2019
  text: 20190710
  day: 10
PublicationDecade 2010
PublicationYear 2019
RelatedCompanies Aduro BioTech, Inc
Novartis AG
RelatedCompanies_xml – name: Aduro BioTech, Inc
– name: Novartis AG
Score 3.2118893
Snippet The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic...
SourceID epo
SourceType Open Access Repository
SubjectTerms BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Title LOCKED NUCLEIC ACID CYCLIC DINUCLEOTIDE COMPOUNDS AND USES THEREOF
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190710&DB=EPODOC&locale=&CC=EP&NR=3507367A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_GFPVNp-L8Ig_St2Jrv-bDkC1JWXVrymxlPo2sS2Ev3XAV_30vZZu-6NtxgeMS-N1XcheAu9wOpKdsZRZ-3jHd3C3MR6ejTB2Lz3xHogHUvcOj2B9k7vPEmzRgse2FqeeEftXDERFROeK9qu316qeIxeq3lev72QJZy6cw7TJjkx2jd0OPabB-lyeCCWpQipQRj7sOxj2OH_QwUdrDKDrQYOBvfd2UsvrtUcJj2E9QWFmdQEOVLTik24_XWnAw2tx3I7mB3voU-kNBXzgjcUaHPKKkRyNG6DsdIs2imivSiHFCxSgRWcxeSS9mJEN7SdIBH3MRngEJeUoHJioz3W18ypOd2s45NMtlqS6ASARKbhVeYBcP7tzyZSBtJXVXqSWl63Xa0P5TzOU_a1dwpE9QFy5t6xqa1cenukGPW81u67P6BpzSfsc
link.rule.ids 230,309,783,888,25576,76876
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5KFetNq2J97kFyCybmVQ9F2t0Nic2Lmkg9lW3cQC9psRH_vpPQVi96G2ZhmF345rU7swB3ue4IS-pSLey8r5q5WaiPRl-qdSw-tw2BBrDuHQ4j28vM56k1bcFi2wvTzAn9aoYjIqJyxHvV2OvVTxGLNW8r1_fzBbKWT246YMomO0bvhh5TYaMBT2IWU4VSpJRoMjAw7jFsZ4iJ0h5G2E4NBv46qptSVr89insE-wkKK6tjaMmyCx26_XitCwfh5r4byQ301icwCmI65oxEGQ24T8mQ-ozQNxogzfyGG6c-44TGYRJnEXshw4iRDO0lST0-4bF7CsTlKfVUVGa22_iMJzu1jTNol8tSngMRCJRcKyxHLx7Md80WjtClqLtKNSFMq9-D3p9iLv5Zu4WOl4bBLPCj8SUc1qdZFzF17Qra1cenvEbvW81vmnP7Brpqgbo
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=LOCKED+NUCLEIC+ACID+CYCLIC+DINUCLEOTIDE+COMPOUNDS+AND+USES+THEREOF&rft.inventor=CANHAM%2C+Stephen&rft.inventor=MCKENNA%2C+Jeffrey&rft.inventor=KANNE%2C+David%2C+Braun&rft.inventor=LE%2C+Thanh+Ngoc+Lan&rft.inventor=NDUBAKU%2C+Chudi%2C+Obioma&rft.inventor=BRUML%2C+Jacob%2C+Robert&rft.inventor=TRIA%2C+George%2C+Scott&rft.date=2019-07-10&rft.externalDBID=A1&rft.externalDocID=EP3507367A1