MULTI-SPECIFIC MOLECULES
The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a first target antigen or epitope, the BDM being modified for se...
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Format | Patent |
Language | English French German |
Published |
02.01.2019
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Abstract | The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide. |
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AbstractList | The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide. |
Author | ROBERTS, Anthony Simon KOPSIDAS, George LUKE, Michael Ross JENNINGS, Phil Anthony |
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DocumentTitleAlternate | MOLÉCULES MULTI-SPÉCIFIQUES MULTISPEZIFISCHE MOLEKÜLE |
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RelatedCompanies | Imunexus Pty Ltd |
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Snippet | The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The... |
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Title | MULTI-SPECIFIC MOLECULES |
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