SYSTEMS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE
A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The devic...
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Main Authors | , , , , , |
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Format | Patent |
Language | English French German |
Published |
01.12.2021
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Abstract | A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels' inlets. |
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AbstractList | A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels' inlets. |
Author | NOHILLY, Martin BORENSTEIN, Jeffrey T DIBIASIO, Christopher WILSON, Jonathan CHAREST, Joseph L LAURENZI, Mark |
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DocumentTitleAlternate | SYSTEME ZUR ERHÖHUNG DES KONVEKTIVEN SPIELRAUMS UNERWÜNSCHTER PARTIKEL IN EINER MIKROFLUIDISCHEN VORRICHTUNG SYSTÈMES POUR L'AUGMENTATION DE LA CLAIRANCE CONVECTIVE DE PARTICULES INDÉSIRABLES DANS UN DISPOSITIF MICROFLUIDIQUE |
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RelatedCompanies | The Charles Stark Draper Laboratory, Inc Johnson & Johnson Innovation LLC |
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Snippet | A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic... |
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SubjectTerms | DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION TRANSPORTING |
Title | SYSTEMS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE |
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