OPTIMIZED RATIOS OF AMINO ACIDS AND SUGARS AS AMORPHOUS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS CONTAINING HIGH CONCENTRATIONS OF PROTEIN-BASED THERAPEUTIC AGENTS
The present invention relates to improved pharmaceutical compositions that contain high concentrations of one or more protein biomolecule(s). In particular, the invention relates to pharmaceutical compositions that include an optimized ratio of protein biomolecule to an amorphous stabilizing compoun...
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Format | Patent |
Language | English French German |
Published |
10.10.2018
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Abstract | The present invention relates to improved pharmaceutical compositions that contain high concentrations of one or more protein biomolecule(s). In particular, the invention relates to pharmaceutical compositions that include an optimized ratio of protein biomolecule to an amorphous stabilizing compound or compounds, especially a sugar, such as sucrose, trehalose, glucose, lactose or sorbitol, or mixtures thereof, or one or more amino acid molecules such as arginine, alanine, glycine, lysine or proline, or derivatives and salts thereof, or mixtures thereof. The inclusion of such amorphous stabilizing compound(s), at such optimized ratio, provides acceptable long-term stability of the protein biomolecule, and facilitates shorter lyophilization time, more specifically shorter drying time, even more specifically shorter primary drying time. |
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AbstractList | The present invention relates to improved pharmaceutical compositions that contain high concentrations of one or more protein biomolecule(s). In particular, the invention relates to pharmaceutical compositions that include an optimized ratio of protein biomolecule to an amorphous stabilizing compound or compounds, especially a sugar, such as sucrose, trehalose, glucose, lactose or sorbitol, or mixtures thereof, or one or more amino acid molecules such as arginine, alanine, glycine, lysine or proline, or derivatives and salts thereof, or mixtures thereof. The inclusion of such amorphous stabilizing compound(s), at such optimized ratio, provides acceptable long-term stability of the protein biomolecule, and facilitates shorter lyophilization time, more specifically shorter drying time, even more specifically shorter primary drying time. |
Author | PANSARE, Swapnil, K PATEL, Sajal, M |
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DocumentTitleAlternate | RAPPORTS OPTIMISÉS D'ACIDES AMINÉS ET DE SUCRES EN TANT QUE COMPOSÉS STABILISANTS AMORPHES DANS DES COMPOSITIONS PHARMACEUTIQUES CONTENANT DES CONCENTRATIONS ÉLEVÉES D'AGENTS THÉRAPEUTIQUES À BASE DE PROTÉINE OPTIMIERTE VERHÄLTNISSE VON AMINOSÄUREN UND ZUCKERN ALS AMORPHE STABILISIERENDE VERBINDUNGEN IN PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN MIT HOHEN KONZENTRATIONEN AN PROTEINBASIERTEN THERAPEUTIKA |
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RelatedCompanies | Medimmune, LLC |
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Snippet | The present invention relates to improved pharmaceutical compositions that contain high concentrations of one or more protein biomolecule(s). In particular,... |
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Title | OPTIMIZED RATIOS OF AMINO ACIDS AND SUGARS AS AMORPHOUS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS CONTAINING HIGH CONCENTRATIONS OF PROTEIN-BASED THERAPEUTIC AGENTS |
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