HYDROXYALKYL THIADIAZOLE DERIVATIVES
Problem to be solved. There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against sensitive bacteria, but also against resistant bacteria thereof, and at the same time possess excellent solubility and safety profile amenable...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | English French German |
Published |
08.08.2018
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Online Access | Get full text |
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Abstract | Problem to be solved. There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against sensitive bacteria, but also against resistant bacteria thereof, and at the same time possess excellent solubility and safety profile amenable to human use. Solution to the Problem. As a result of intensive research, the present inventors have found that a compound represented by general formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof inhibits DNA gyrase GyrB subunit and/or topoisomerase IV ParE subunit, possess excellent solubility and safety profile for use in human for the treatment of bacterial infectious diseases. |
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AbstractList | Problem to be solved. There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against sensitive bacteria, but also against resistant bacteria thereof, and at the same time possess excellent solubility and safety profile amenable to human use. Solution to the Problem. As a result of intensive research, the present inventors have found that a compound represented by general formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof inhibits DNA gyrase GyrB subunit and/or topoisomerase IV ParE subunit, possess excellent solubility and safety profile for use in human for the treatment of bacterial infectious diseases. |
Author | KAGOSHIMA, Yoshiko SATTIGERI, Jitendra A MASUDA, , Nobuhisa SUZUKI, Tetsuya ITOOKA, Ryo KONOSU, Toshiyuki KHERA, Manoj Kumar SONEDA, Tsuyoshi YAMAOKA, Makoto MATHUR, Tarun |
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DocumentTitleAlternate | HYDROXYALKYLTHIADIAZOLDERIVATE DÉRIVÉS D'HYDROXYALKYLTHIADIAZOLE |
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RelatedCompanies | Daiichi Sankyo Company, Limited |
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Snippet | Problem to be solved. There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against... |
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Title | HYDROXYALKYL THIADIAZOLE DERIVATIVES |
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