FACTOR XIA INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibi...

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Main Authors BROCKUNIER, Linda, L, ALI, Amjad, SO, Sung-Sau, MONINGKA, Remond, NEELAMKAVIL, Santhosh, F, LIU, Weiguo, GAO, Ying-Duo, SUN, Wanying, EDMONDSON, Scott, D, HRUZA, Alan, MERTZ, Eric
Format Patent
LanguageEnglish
French
German
Published 27.06.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
AbstractList The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Author EDMONDSON, Scott, D
NEELAMKAVIL, Santhosh, F
SUN, Wanying
LIU, Weiguo
BROCKUNIER, Linda, L
MERTZ, Eric
MONINGKA, Remond
HRUZA, Alan
GAO, Ying-Duo
SO, Sung-Sau
ALI, Amjad
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– fullname: MONINGKA, Remond
– fullname: NEELAMKAVIL, Santhosh, F
– fullname: LIU, Weiguo
– fullname: GAO, Ying-Duo
– fullname: SUN, Wanying
– fullname: EDMONDSON, Scott, D
– fullname: HRUZA, Alan
– fullname: MERTZ, Eric
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DocumentTitleAlternate INHIBITEURS DU FACTOR XIA
FAKTOR-XIA-HEMMER
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Snippet The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title FACTOR XIA INHIBITORS
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