NOVEL ARYL-CYANOGUANIDINE COMPOUNDS

• Main Authors: STÖCKIGT, Detlef, WEISKE, Jörg, STRESEMANN, Carlo, BARACK, Naomi, STELLFELD, Timo, STEFANUTI, Ian, BRUMBY, Thomas, BADOCK, Volker, CHRIST, Clara, KÖHR, Silke, CRAMPTON, Rosemary Helen, TER LAAK, Antonius, MOWAT, Jeffrey Stuart, HILLIG, Roman
• Format: Patent
• Language: English; French; German
• Published: 30.01.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to protein-lysine N-methyltransferase SMYD2 (SET and MYND domain-containing protein 2) inhibitors, in particular SMYD2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (I) wherein R1, R2, R3, R4, R5, X and r have the meaning as described and defined...