METHYL-AND TRIFLUOROMETHYL-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF

• Main Authors: MENTE, Scot Richard, ZHANG, Liying, TRZUPEK, John David, ZAMARATSKI, Edouard, XING, Li, FLICK, Andrew Christopher, JONES, Peter, SCHNUTE, Mark Edward, WENNERSTÅL, Göran Mattias, KAILA, Neelu, VAZQUEZ, Michael L
• Format: Patent
• Language: English; French; German
• Published: 02.08.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharma...