PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE

The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the splic...

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Main Authors LIM, Kian Huat, GERARD, Baudouin, PARK, Eunice Sun, KIRA, Kazunobu, BUONAMICI, Silvia, ZHENG, Guo Zhu, TIVITMAHAISOON, Parcharee, GEARHART, Nicholas C, YU, Lihua, MURAI, Norio, KANADA SONOBE, Regina, ARAI, Kenzo, KOTAKE, Yoshihiko, NAGAO, Satoshi, WANG, John, CHAN, Betty, THOMAS, Michael P, MIYANO, Masayuki, SMITH, Peter G, PRAJAPATI, Sudeep, KEANEY, Gregg F, PAZOLLI, Ermira, LIU, Xiang
Format Patent
LanguageEnglish
French
German
Published 22.03.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
Bibliography:Application Number: EP20150727125