CHELATE-CONTROLLED DIASTEREOSELECTIVE HYDROGENATION WITH HETEROGENEOUS CATALYST

• Main Authors: SUTTON, Howard Winston Tyrrell, ROGAN, Yulia, GIBBINGS, Matthew Richard, HUTCHINGS, Lian, ANDERSON, Craig, GRANT, Simon Jonathon, GAMBOA MARTINEZ, Sergio Aaron, DUNN, David, DALY, John Ing Chuan, RIBIERE, Patrice Georges Antonin
• Format: Patent
• Language: English; French; German
• Published: 01.03.2017
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

A hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support, is used in the presence of lithium salts, with salts such as the borates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselec...