PYRROLE-SUBSTITUTED INDOLONE DERIVATIVE, PREPARATION METHOD THEREFOR, COMPOSITION COMPRISING SAME AND USE THEREOF

The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising the derivative, and use thereof. The pyrrole-substituted indolone derivative has a structure shown in formula (I) below. The present invention further relates to use of...

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Main Authors AN, Junyong, ZHANG, Lili, ZHOU, Mengxia, YAO, Zijian, HU, Lihong, ZHAO, Shaohua, LI, Xiangjun, LIU, Peng
Format Patent
LanguageEnglish
French
German
Published 04.07.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising the derivative, and use thereof. The pyrrole-substituted indolone derivative has a structure shown in formula (I) below. The present invention further relates to use of the pyrrole-substituted indolone derivative for treating receptor tyrosine kinase-mediated diseases, and to a pharmaceutical composition comprising compounds having such a structure for treating related diseases such as tumors.
Bibliography:Application Number: EP20150746066